Rhinova Biotech · Regenerative nasal medicine
Rhinova Biotech is developing patient-specific bone and cartilage, combining regenerative medicine with 3D precision to restore nasal anatomy, function, and natural form.
In development. Not approved for clinical use.
The problem
Patients can lose or damage nasal bone and cartilage through trauma, cancer, military injury, congenital conditions, animal bites, and complications from previous surgery.
58%
of facial-fracture-related U.S. emergency department visits involved the nasal bone, making it the most commonly involved facial structure.
5–15%
Published studies report rhinoplasty revision rates within this range.
11%
subsequent revision rate was reported among patients already undergoing secondary septorhinoplasty in a large U.S. cohort.
27.5%
of nasal fractures in a large national trauma study were associated with motor vehicle accidents.
Behind every statistic is the same challenge: rebuilding complex anatomy while restoring structure, function, and identity.
Existing solutions
Today's nasal reconstruction often relies on harvesting cartilage or bone from the rib, ear, septum, or other parts of the body. This can require an additional surgical site, increase operative time, and expose patients to additional pain, scarring, and donor-site complications.
Surgeons must manually shape and assemble grafts to recreate complex anatomy, with risks of warping, resorption, and revision. Rhinova is developing a patient-specific, 3D-fabricated approach designed for greater precision and predictability.
Current sources
Cadaveric tissue avoids harvesting from the patient, but can still have limitations in resorption, shaping, carving, integration and predictability.
Rhinova started from the opposite conviction: tissue should be regenerated, not borrowed.
Our solution
Rhinova is developing patient-specific bone and cartilage components designed using medical imaging, computer-aided design, and 3D fabrication technologies. The goal is to recreate complex nasal anatomy with greater precision while restoring structural support, airflow, natural contour, and facial form.
Medical imaging, existing anatomy, and — when available — preoperative photographs or other anatomical references can inform the reconstructive plan.
Computer-aided design is used to create patient-specific bone and cartilage components based on the intended anatomical and functional outcome.
Patient-specific scaffolds are fabricated using 3D manufacturing technologies and regenerative biomaterials. Cartilage approaches may incorporate patient-derived cells and tissue maturation prior to implantation.
The resulting components are designed for surgical reconstruction of nasal anatomy, with the goal of restoring structural support, natural contour, and airflow.
Regenerating patient-specific bone.
Osteoconductive regenerative constructs designed to restore anatomy, structural support, contour, and functional relationships within the nose.
Regenerating patient-specific cartilage.
Cell-based regenerative constructs designed to recreate patient-specific cartilage anatomy and restore support, airflow, and natural form.
Traditional reconstruction relies heavily on manually carving and shaping grafts during surgery. Rhinova's vision is to move more of that precision into the design and fabrication process — creating patient-specific components before implantation rather than relying solely on intraoperative carving.
The goal: greater anatomical precision, greater reproducibility, and potentially less time spent harvesting and manually shaping grafts during surgery.
Nasal anatomy determines both form and function. Small changes in the septum, nasal valves, cartilage, and surrounding structures can significantly affect airflow. Rhinova's patient-specific approach is being designed with both external anatomy and internal function in mind. Over time, computational modeling such as computational fluid dynamics may help evaluate how reconstructive designs could affect nasal airflow.
Rhinova's technology is in development and is not approved for clinical use or currently available to patients.
The vision
Rhinova gives patients back what they lost, while minimizing donor-site morbidity.
The path
From scan to implant: our path to first-in-human.
2026
Rhinova is established to advance patient-specific regenerative solutions for nasal reconstruction.
Stage 2
Build the research and manufacturing partnerships and define the product architecture.
Stage 3
Refine patient-specific design and fabrication while evaluating anatomical fit, bone-cartilage integration, biocompatibility, surgical handling, and functional performance.
Stage 4
Advance scalable manufacturing, quality systems, and preclinical studies toward standardized GMP production and regulatory submission.
Stage 5
Subject to successful preclinical development and regulatory authorization, initiate an early clinical study of Rhinova's bone and cartilage implant for nasal reconstruction.
Beyond
Explore additional applications across complex nasal and craniofacial reconstruction, including more advanced bone and cartilage reconstruction and, where scientifically feasible, other anatomically related tissues and defects.
The timing of each stage depends on funding, technical results and regulatory authorization.
Team
Rhinova was founded from firsthand experience with complex nasal reconstruction. We are building toward a future where reconstruction can restore health, anatomy, function, and a patient's sense of self — without requiring extensive tissue harvesting elsewhere in the body.
Chief Executive Officer
Ana is a pharmacist with experience in pharma, MedTech and healthcare business development. As CEO, she leads Rhinova's strategy, partnerships and fundraising, and brings the science, clinical partners and funding together.
Chief Marketing Officer
Katharine leads Rhinova’s brand, marketing, and communications. With a background in media and storytelling, she focuses on translating complex science into clear, compelling narratives for patients, partners, and the regenerative medicine community.
Open role
We're looking for a scientist in tissue engineering or regenerative medicine to join as a co-founder and lead technical development.
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